Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.L85S

c.254T>C

Surrounding Variants

1 paper

NM_138554.5

p.S86P

c.256T>C

1 paper

NM_138554.5

p.D84G

c.251A>G

6 papers

NM_138554.5

p.D84V

c.251A>T

1 paper

NM_138554.5

p.S86F

c.257C>T

1 paper

NM_138554.5

p.D84_L85insT

c.250_254ins3

1 paper

NM_138554.5

p.R87T

c.260G>C

1 paper

NM_138554.5

p.R87Splc

c.260+1G>T

1 paper

NM_138554.5

p.V82E

c.245T>A

1 paper

NM_138554.5

p.V82A

c.245T>C

1 paper

NM_138554.5

p.V82G

c.245T>G

2 papers

NM_138554.5

p.V82M

c.244G>A

1 paper

NM_138554.5

p.L80M

c.238C>A