Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.S100G

c.298A>G

Surrounding Variants

1 paper

NM_138554.5

p.S100C

c.298A>T

2 papers

NM_138554.5

p.S100N

c.299G>A

1 paper

NM_138554.5

p.Q99E

c.295C>G

2 papers

NM_138554.5

p.Y98C

c.293A>G

2 papers

NM_138554.5

p.Y98D

c.292T>G

1 paper

NM_138554.5

p.A97V

c.290C>T

5 papers

NM_138554.5

p.H103R

c.308A>G

1 paper

NM_138554.5

p.L104I

c.310C>A

1 paper

NM_138554.5

p.L104F

c.310C>T

1 paper

NM_138554.5

p.G96R

c.286G>A

1 paper

NM_138554.5

p.E94D

c.282A>C

1 paper

NM_138554.5

p.E94D

c.282A>T