Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.L109L

c.327G>A

Surrounding Variants

1 paper

NM_138554.5

p.L109L

c.325T>C

1 paper

NM_138554.5

p.I108L

c.322A>T

1 paper

NM_138554.5

p.G111G

c.333A>G

1 paper

NM_138554.5

p.N112S

c.335A>G

1 paper

NM_138554.5

p.T106T

c.318C>A

1 paper

NM_138554.5

p.T106T

c.318C>T

1 paper

NM_138554.5

p.P113S

c.337C>T

1 paper

NM_138554.5

p.P113P

c.339C>T

1 paper

NM_003266.4

p.S65S

c.195T>C

1 paper

NM_138554.5

p.I114T

c.341T>C

1 paper

NM_138554.5

p.Q115_L117delFs

c.344_351del8

1 paper

NM_138554.5

p.L104I

c.310C>A