Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.L125V

c.373C>G

Surrounding Variants

1 paper

NM_138554.5

p.L125Q

c.374T>A

1 paper

NM_138554.5

p.G124R

c.370G>A

1 paper

NM_138554.5

p.G124R

c.370G>C

1 paper

NM_138554.5

p.S126T

c.376T>A

1 paper

NM_138554.5

p.S123S

c.369T>C

1 paper

NM_138554.5

p.S123F

c.368C>T

1 paper

NM_138554.5

p.S127G

c.379A>G

1 paper

NM_138554.5

p.S127S

c.381T>C

1 paper

NM_138554.5

p.F122V

c.364T>G

1 paper

NM_138554.5

p.Q129R

c.386A>G

1 paper

NM_138554.5

p.G120V

c.359G>T

1 paper

NM_138554.5

p.L119M

c.355C>A