Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003266.4

p.E102D

c.306G>C

Surrounding Variants

2 papers

NM_138554.5

p.N143N

c.429C>T

1 paper

NM_138554.5

p.F144S

c.431T>C

1 paper

NM_138554.5

p.F144F

c.432C>T

2 papers

NM_138554.5

p.P145L

c.434C>T

1 paper

NM_138554.5

p.A139E

c.416C>A

1 paper

NM_138554.5

p.G147R

c.439G>A

1 paper

NM_138554.5

p.G147R

c.439G>C

1 paper

NM_138554.5

p.L138P

c.413T>C

1 paper

NM_138554.5

p.L138L

c.412C>T

1 paper

NM_138554.5

p.G147E

c.440G>A

1 paper

NM_138554.5

p.N137S

c.410A>G

1 paper

NM_138554.5

p.N137Y

c.409A>T