Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.L149F

c.445C>T

Surrounding Variants

1 paper

NM_138554.5

p.H148Q

c.444T>A

1 paper

NM_138554.5

p.H148Q

c.444T>G

1 paper

NM_138554.5

p.H148L

c.443A>T

1 paper

NM_138554.5

p.K150T

c.449A>C

1 paper

NM_138554.5

p.G147E

c.440G>A

1 paper

NM_138554.5

p.T151S

c.451A>T

1 paper

NM_138554.5

p.G147R

c.439G>A

1 paper

NM_138554.5

p.G147R

c.439G>C

1 paper

NM_138554.5

p.T151S

c.452C>G

1 paper

NM_138554.5

p.T151I

c.452C>T

2 papers

NM_138554.5

p.P145L

c.434C>T

1 paper

NM_138554.5

p.K153T

c.458A>C