Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.E178D

c.534G>T

Surrounding Variants

1 paper

NM_138554.5

p.H179D

c.535C>G

1 paper

NM_138554.5

p.L177L

c.531A>G

1 paper

NM_138554.5

p.L177L

c.529C>T

1 paper

NM_138554.5

p.N176T

c.527A>C

1 paper

NM_138554.5

p.D181Y

c.541G>T

1 paper

NM_138554.5

p.N176fs

c.526_527fs

1 paper

NM_138554.5

p.D181E

c.543C>A

1 paper

NM_138554.5

p.D181E

c.543C>G

5 papers

NM_138554.5

p.T175A

c.523A>G

1 paper

NM_138554.5

p.S183A

c.547T>G

1 paper

NM_138554.5

p.N176_L182delFs

c.526_544del19

1 paper

NM_138554.5

p.N173K

c.519T>A