Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_138554.5

p.K224N

c.672A>C

Surrounding Variants

1 paper

NM_138554.5

p.K224N

c.672A>T

1 paper

NM_138554.5

p.E225K

c.673G>A

1 paper

NM_138554.5

p.E225*

c.673G>T

1 paper

NM_138554.5

p.K224E

c.670A>G

1 paper

NM_138554.5

p.E225D

c.675A>C

1 paper

NM_138554.5

p.E225D

c.675A>T

1 paper

NM_138554.5

p.F223F

c.669T>C

1 paper

NM_138554.5

p.I226V

c.676A>G

1 paper

NM_138554.5

p.I226S

c.677T>G

1 paper

NM_138554.5

p.R227W

c.679A>T

1 paper

NM_138554.5

p.A222V

c.665C>T

1 paper

NM_138554.5

p.R227R

c.681G>A