Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_138554.5

p.L260P

c.779T>C

Surrounding Variants

1 paper

NM_138554.5

p.G261E

c.782G>A

2 papers

NM_138554.5

p.L258F

c.774G>C

2 papers

NM_138554.5

p.L258F

c.774G>T

1 paper

NM_138554.5

p.E262G

c.785A>G

1 paper

NM_138554.5

p.L258L

c.772T>C

2 papers

NM_138554.5

p.R257C

c.769C>T

1 paper

NM_138554.5

p.R264*

c.790A>T

2 papers

NM_138554.5

p.V255V

c.765C>G

1 paper

NM_138554.5

p.E254E

c.762A>G

1 paper

NM_138554.5

p.E266K

c.796G>A

1 paper

NM_138554.5

p.E254K

c.760G>A

3 papers

NM_138554.5

p.G267E

c.800G>A