Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.S275A

c.823T>G

Surrounding Variants

2 papers

NM_138554.5

p.K274N

c.822A>C

2 papers

NM_138554.5

p.K274N

c.822A>T

1 paper

NM_138554.5

p.A276T

c.826G>A

5 papers

NM_138554.5

p.D273D

c.819C>T

1 paper

NM_138554.5

p.L277L

c.831A>T

1 paper

NM_138554.5

p.K271T

c.812A>C

1 paper

NM_138554.5

p.K271_A276del0

c.811_828del18

1 paper

NM_138554.5

p.G279D

c.836G>A

1 paper

NM_138554.5

p.E270A

c.809A>C

3 papers

NM_138554.5

p.L280M

c.838C>A

1 paper

NM_138554.5

p.L269L

c.807G>A

1 paper

NM_138554.5

p.N268K

c.804C>A