Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.E287G

c.860A>G

Surrounding Variants

1 paper

NM_138554.5

p.F288I

c.862T>A

2 papers

NM_138554.5

p.E286G

c.857A>G

1 paper

NM_138554.5

p.E286V

c.857A>T

1 paper

NM_138554.5

p.R289delFs

c.865delC

1 paper

NM_138554.5

p.R289*

c.865C>T

4 papers

NM_138554.5

p.R289Q

c.866G>A

1 paper

NM_138554.5

p.L290*

c.869T>A

5 papers

NM_138554.5

p.L290S

c.869T>C

NM_003266.4

p.L250S

c.749T>C

1 paper

NM_138554.5

p.L290*

c.869T>G

10 papers

NM_138554.5

p.Y292N

c.874T>A

1 paper

NM_138554.5

p.Y292D

c.874T>G

2 papers

NM_138554.5

p.N282S

c.845A>G