Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.L303S

c.908T>C

Surrounding Variants

1 paper

NM_138554.5

p.L303V

c.907T>G

1 paper

NM_138554.5

p.F304L

c.910T>C

1 paper

NM_138554.5

p.F304V

c.910T>G

1 paper

NM_138554.5

p.N305fs

c.913_914fs

1 paper

NM_138554.5

p.N305insFs

c.914_915ins13

1 paper

NM_138554.5

p.N305T

c.914A>C

1 paper

NM_138554.5

p.N305S

c.914A>G

3 papers

NM_138554.5

p.N305I

c.914A>T

2 papers

NM_138554.5

p.I301T

c.902T>C

1 paper

NM_138554.5

p.I300M

c.900T>G

1 paper

NM_138554.5

p.C306_L307ins11

c.918_919ins33

2 papers

NM_138554.5

p.C306W

c.918T>G