Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_138554.5

p.S317N

c.950G>A

Surrounding Variants

1 paper

NM_138554.5

p.S317insFs

c.949_950insA

1 paper

NM_138554.5

p.V318E

c.953T>A

1 paper

NM_138554.5

p.L315L

c.945G>A

1 paper

NM_138554.5

p.T319N

c.956C>A

1 paper

NM_138554.5

p.L315insFs

c.944_945insG

1 paper

NM_138554.5

p.I320S

c.959T>G

1 paper

NM_138554.5

p.I320I

c.960T>C

2 papers

NM_138554.5

p.E321G

c.962A>G

1 paper

NM_138554.5

p.S312A

c.934T>G

1 paper

NM_138554.5

p.S311insFs

c.931_932insA

2 papers

NM_138554.5

p.V310G

c.929T>G

1 paper

NM_138554.5

p.V310F

c.928G>T