Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_138554.5

p.G343E

c.1028G>A

Surrounding Variants

1 paper

NM_138554.5

p.Q344_K351del8

c.1030_1052del24

1 paper

NM_138554.5

p.F342Y

c.1025T>A

1 paper

NM_138554.5

p.K341R

c.1022A>G

1 paper

NM_138554.5

p.P346H

c.1037C>A

3 papers

NM_138554.5

p.T347K

c.1040C>A

1 paper

NM_138554.5

p.K349E

c.1045A>G

1 paper

NM_138554.5

p.E336D

c.1008A>T

1 paper

NM_138554.5

p.L350F

c.1048C>T

1 paper

NM_138554.5

p.E336insFs

c.1007_1008insC

1 paper

NM_138554.5

p.L350L

c.1050C>T

2 papers

NM_138554.5

p.L353F

c.1057C>T

3 papers

NM_138554.5

p.K354K

c.1062A>G