Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.S360P

c.1078T>C

Surrounding Variants

8 papers

NM_138554.5

p.T359I

c.1076C>T

2 papers

NM_138554.5

p.S360S

c.1080C>T

1 paper

NM_138554.5

p.N361Y

c.1081A>T

11 papers

NM_138554.5

p.N361S

c.1082A>G

2 papers

NM_138554.5

p.K362E

c.1084A>G

1 paper

NM_138554.5

p.L356V

c.1066C>G

1 paper

NM_138554.5

p.R355S

c.1065G>T

1 paper

NM_138554.5

p.N365insFs

c.1094dupA

25 papers

NM_138554.5

p.R355G

c.1063A>G

3 papers

NM_138554.5

p.K354K

c.1062A>G

1 paper

NM_138554.5

p.N365N

c.1095T>C

2 papers

NM_138554.5

p.A366T

c.1096G>A