Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_138554.5

p.G389_C390insFs

c.1167_1168insC

Surrounding Variants

1 paper

NM_138554.5

p.G389G

c.1167T>C

2 papers

NM_138554.5

p.G389S

c.1165G>A

1 paper

NM_138554.5

p.G389R

c.1165G>C

1 paper

NM_138554.5

p.K388E

c.1162A>G

2 papers

NM_138554.5

p.S386N

c.1157G>A

3 papers

NM_003266.4

p.L345F

c.1035G>C

NM_138554.5

p.L385F

c.1155G>C

3 papers

NM_003266.4

p.L345F

c.1035G>T

NM_138554.5

p.L385F

c.1155G>T

1 paper

NM_138554.5

p.S394G

c.1180A>G

1 paper

NM_138554.5

p.S394C

c.1180A>T

1 paper

NM_138554.5

p.D395Y

c.1183G>T

1 paper

NM_138554.5

p.R382G

c.1144A>G

4 papers

NM_138554.5

p.T398T

c.1194A>G