Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.Q423L

c.1268A>T

Surrounding Variants

1 paper

NM_138554.5

p.L421L

c.1263A>G

1 paper

NM_138554.5

p.G420S

c.1258G>A

2 papers

NM_138554.5

p.L427P

c.1280T>C

1 paper

NM_138554.5

p.N417N

c.1251C>T

2 papers

NM_138554.5

p.S416*

c.1247C>A

2 papers

NM_138554.5

p.S416*

c.1247C>G

1 paper

NM_138554.5

p.S416A

c.1246T>G

1 paper

NM_138554.5

p.S432Y

c.1295C>A

1 paper

NM_138554.5

p.S432S

c.1296C>T

2 papers

NM_138554.5

p.N433T

c.1298A>C

1 paper

NM_138554.5

p.I412I

c.1236T>C

1 paper

NM_138554.5

p.I412F

c.1234A>T