Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.D453G

c.1358A>G

Surrounding Variants

1 paper

NM_138554.5

p.L452P

c.1355T>C

2 papers

NM_138554.5

p.L452R

c.1355T>G

1 paper

NM_138554.5

p.S455F

c.1364C>T

1 paper

NM_138554.5

p.S455S

c.1365T>C

1 paper

NM_138554.5

p.H456Y

c.1366C>T

10 papers

NM_138554.5

p.I450I

c.1350T>C

1 paper

NM_138554.5

p.H458L

c.1373A>T

1 paper

NM_138554.5

p.T459A

c.1375A>G

1 paper

NM_138554.5

p.R447*

c.1339A>T

2 papers

NM_138554.5

p.T459T

c.1377C>T

1 paper

NM_138554.5

p.L446V

c.1336C>G

1 paper

NM_138554.5

p.V461L

c.1381G>C