Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_138554.5

p.G465S

c.1393G>A

Surrounding Variants

1 paper

NM_138554.5

p.G465C

c.1393G>T

2 papers

NM_138554.5

p.I466I

c.1398C>T

1 paper

NM_138554.5

p.A462V

c.1385C>T

1 paper

NM_138554.5

p.V461G

c.1382T>G

1 paper

NM_138554.5

p.V461L

c.1381G>C

1 paper

NM_138554.5

p.G469D

c.1406G>A

2 papers

NM_138554.5

p.T459T

c.1377C>T

1 paper

NM_138554.5

p.L470F

c.1410G>C

1 paper

NM_138554.5

p.L470F

c.1410G>T

1 paper

NM_138554.5

p.T459A

c.1375A>G

1 paper

NM_138554.5

p.H458L

c.1373A>T

1 paper

NM_138554.5

p.L473P

c.1418T>C