Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.A479T

c.1435G>A

Surrounding Variants

1 paper

NM_138554.5

p.G480C

c.1438G>T

2 papers

NM_138554.5

p.S482F

c.1445C>T

1 paper

NM_138554.5

p.E474G

c.1421A>G

10 papers

NM_138554.5

p.E474K

c.1420G>A

NM_003266.4

p.E434K

c.1300G>A

1 paper

NM_138554.5

p.L473P

c.1418T>C

1 paper

NM_138554.5

p.E485K

c.1453G>A

2 papers

NM_138554.5

p.N486T

c.1457A>C

1 paper

NM_138554.5

p.N486K

c.1458C>A

2 papers

NM_138554.5

p.F487L

c.1459T>C

2 papers

NM_138554.5

p.F487V

c.1459T>G

1 paper

NM_138554.5

p.L470F

c.1410G>C

1 paper

NM_138554.5

p.L470F

c.1410G>T