Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_138554.5

p.L498V

c.1492T>G

Surrounding Variants

1 paper

NM_138554.5

p.L495P

c.1484T>C

1 paper

NM_138554.5

p.F492L

c.1476C>A

1 paper

NM_138554.5

p.F492L

c.1476C>G

1 paper

NM_138554.5

p.F492L

c.1474T>C

1 paper

NM_138554.5

p.S504P

c.1510T>C

2 papers

NM_138554.5

p.F492V

c.1474T>G

2 papers

NM_138554.5

p.Q505R

c.1514A>G

2 papers

NM_003266.4

p.D450D

c.1350T>C

NM_138554.5

p.D490D

c.1470T>C

1 paper

NM_138554.5

p.P489L

c.1466C>T

1 paper

NM_138554.5

p.C506*

c.1518T>A

2 papers

NM_138554.5

p.C506W

c.1518T>G

2 papers

NM_138554.5

p.F487L

c.1461C>A