Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_138554.5

p.D536D

c.1608T>C

Surrounding Variants

1 paper

NM_138554.5

p.T537M

c.1610C>T

3 papers

NM_138554.5

p.L535F

c.1605G>C

3 papers

NM_138554.5

p.L535F

c.1605G>T

1 paper

NM_138554.5

p.S534*

c.1601C>A

1 paper

NM_138554.5

p.S534*

c.1601C>G

2 papers

NM_138554.5

p.Y540C

c.1619A>G

1 paper

NM_138554.5

p.F532L

c.1596C>A

1 paper

NM_138554.5

p.F532L

c.1596C>G

1 paper

NM_138554.5

p.K541delFs

c.1623delG

1 paper

NM_138554.5

p.F532L

c.1594T>C

1 paper

NM_138554.5

p.N531K

c.1593C>A

1 paper

NM_138554.5

p.N531K

c.1593C>G