Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.S559Y

c.1676C>A

Surrounding Variants

1 paper

NM_138554.5

p.S559F

c.1676C>T

1 paper

NM_138554.5

p.K560R

c.1679A>G

2 papers

NM_138554.5

p.N554S

c.1661A>G

1 paper

NM_138554.5

p.H566Y

c.1696C>T

1 paper

NM_138557.3

p.F367delFs

c.1100delT

1 paper

NM_138554.5

p.Y551C

c.1652A>G

1 paper

NM_138554.5

p.P568T

c.1702C>A

1 paper

NM_138554.5

p.P568S

c.1702C>T

1 paper

NM_138554.5

p.D550A

c.1649A>C

1 paper

NM_138554.5

p.S570I

c.1709G>T

2 papers

NM_138554.5

p.L571P

c.1712T>C

1 paper

NM_138554.5

p.Q547K

c.1639C>A