Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.C585R

c.1753T>C

Surrounding Variants

1 paper

NM_138554.5

p.T584S

c.1751C>G

1 paper

NM_138554.5

p.T584S

c.1750A>T

1 paper

NM_138554.5

p.A582D

c.1745C>A

1 paper

NM_138554.5

p.Q588Q

c.1764G>A

1 paper

NM_138554.5

p.F581fs

c.1741_1742fs

1 paper

NM_138554.5

p.F581delFs

c.1743delT

1 paper

NM_138554.5

p.F590L

c.1770C>G

1 paper

NM_138554.5

p.N579D

c.1735A>G

1 paper

NM_138554.5

p.Q578P

c.1733A>C

1 paper

NM_138554.5

p.Q578R

c.1733A>G

1 paper

NM_138554.5

p.L591L

c.1773G>T

1 paper

NM_138554.5

p.Q592R

c.1775A>G