Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.E605*

c.1813G>T

Surrounding Variants

1 paper

NM_138554.5

p.E605K

c.1813G>A

1 paper

NM_138554.5

p.E603D

c.1809A>C

1 paper

NM_138554.5

p.E603D

c.1809A>T

1 paper

NM_138554.5

p.R606Q

c.1817G>A

4 papers

NM_138554.5

p.E603K

c.1807G>A

1 paper

NM_138554.5

p.V602G

c.1805T>G

1 paper

NM_138557.3

p.C409_A410insFs

c.1227_1228dupTG

1 paper

NM_138554.5

p.C609R

c.1825T>C

1 paper

NM_138554.5

p.L600H

c.1799T>A

2 papers

NM_138554.5

p.A610V

c.1829C>T

2 papers

NM_138554.5

p.T611A

c.1831A>G

1 paper

NM_138554.5

p.R598K

c.1793G>A