Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.L621M

c.1861C>A

Surrounding Variants

1 paper

NM_138554.5

p.L621L

c.1861C>T

1 paper

NM_138554.5

p.V620_L621del2

c.1858_1862del6

1 paper

NM_138554.5

p.L623L

c.1869G>A

1 paper

NM_138554.5

p.N624T

c.1871A>C

1 paper

NM_138554.5

p.I625F

c.1873A>T

1 paper

NM_138554.5

p.G617C

c.1849G>T

4 papers

NM_138554.5

p.D614G

c.1841A>G

1 paper

NM_138554.5

p.D614N

c.1840G>A

1 paper

NM_138554.5

p.Q628Q

c.1884G>A

1 paper

NM_138554.5

p.N630S

c.1889A>G

2 papers

NM_138554.5

p.T611A

c.1831A>G

2 papers

NM_138554.5

p.A610V

c.1829C>T