Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.S637A

c.1909T>G

Surrounding Variants

1 paper

NM_138554.5

p.V636_L642del7

c.1906_1925del21

1 paper

NM_138554.5

p.I634I

c.1902T>C

1 paper

NM_138554.5

p.I634_V641del8

c.1900_1922del24

1 paper

NM_138554.5

p.N630S

c.1889A>G

1 paper

NM_138554.5

p.Q628Q

c.1884G>A

1 paper

NM_138554.5

p.V646A

c.1937T>C

1 paper

NM_138554.5

p.V647I

c.1939G>A

2 papers

NM_138554.5

p.V647A

c.1940T>C

1 paper

NM_138554.5

p.I625F

c.1873A>T

1 paper

NM_138554.5

p.V649G

c.1946T>G

1 paper

NM_138554.5

p.N624T

c.1871A>C

1 paper

NM_138554.5

p.L623L

c.1869G>A