Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.Q683K

c.2047C>A

Surrounding Variants

1 paper

NM_138554.5

p.D684E

c.2052T>A

1 paper

NM_138554.5

p.D684E

c.2052T>G

1 paper

NM_138554.5

p.I679T

c.2036T>C

1 paper

NM_138554.5

p.I679V

c.2035A>G

1 paper

NM_138554.5

p.W687G

c.2059T>G

1 paper

NM_138554.5

p.R689delFs

c.2067delG

1 paper

NM_138554.5

p.A676A

c.2028C>A

2 papers

NM_138554.5

p.A676A

c.2028C>T

1 paper

NM_138554.5

p.R689K

c.2066G>A

1 paper

NM_138554.5

p.A676G

c.2027C>G

1 paper

NM_138554.5

p.D675D

c.2025T>C

1 paper

NM_138554.5

p.D675N

c.2023G>A