Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.E698A

c.2093A>C

Surrounding Variants

1 paper

NM_138554.5

p.E697G

c.2090A>G

1 paper

NM_138554.5

p.V700A

c.2099T>C

4 papers

NM_138554.5

p.P702S

c.2104C>T

7 papers

NM_138554.5

p.K694R

c.2081A>G

1 paper

NM_138554.5

p.F703C

c.2108T>G

1 paper

NM_138554.5

p.Q704K

c.2110C>A

1 paper

NM_138554.5

p.E691G

c.2072A>G

1 paper

NM_138554.5

p.C706S

c.2116T>A

1 paper

NM_138554.5

p.C706Y

c.2117G>A

1 paper

NM_138554.5

p.C706S

c.2117G>C

1 paper

NM_138554.5

p.R689K

c.2066G>A

1 paper

NM_138554.5

p.R689delFs

c.2067delG