Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.G726C

c.2176G>T

Surrounding Variants

1 paper

NM_138554.5

p.G726V

c.2177G>T

1 paper

NM_138554.5

p.E725A

c.2174A>C

3 papers

NM_138554.5

p.F727V

c.2179T>G

1 paper

NM_138554.5

p.F727F

c.2181C>T

1 paper

NM_138554.5

p.H728N

c.2182C>A

1 paper

NM_138554.5

p.H728D

c.2182C>G

2 papers

NM_138554.5

p.I722V

c.2164A>G

1 paper

NM_003266.4

p.R691G

c.2071C>G

3 papers

NM_138554.5

p.R731*

c.2191C>T

2 papers

NM_138554.5

p.R731Q

c.2192G>A

1 paper

NM_138554.5

p.A720V

c.2159C>T

1 paper

NM_138554.5

p.K732Q

c.2194A>C