Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.Q743H

c.2229G>T

Surrounding Variants

1 paper

NM_138554.5

p.Q743H

c.2229G>C

1 paper

NM_138554.5

p.Q743L

c.2228A>T

2 papers

NM_138554.5

p.R745H

c.2234G>A

2 papers

NM_138554.5

p.W746C

c.2238G>C

2 papers

NM_138554.5

p.W746C

c.2238G>T

3 papers

NM_138554.5

p.C747S

c.2239T>A

1 paper

NM_138554.5

p.H740N

c.2218C>A

1 paper

NM_138554.5

p.H740Y

c.2218C>T

3 papers

NM_138554.5

p.C747S

c.2240G>C

1 paper

NM_138554.5

p.F749L

c.2245T>C

1 paper

NM_138554.5

p.F749L

c.2247T>A

1 paper

NM_138554.5

p.F749L

c.2247T>G