Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.K776N

c.2328G>C

Surrounding Variants

1 paper

NM_138554.5

p.K776N

c.2328G>T

1 paper

NM_138554.5

p.V774M

c.2320G>A

1 paper

NM_138554.5

p.Q781Q

c.2343G>A

1 paper

NM_138554.5

p.V770I

c.2308G>A

1 paper

NM_138554.5

p.F768S

c.2303T>C

1 paper

NM_138554.5

p.Y786H

c.2356T>C

2 papers

NM_138554.5

p.I767V

c.2299A>G

2 papers

NM_138554.5

p.R787C

c.2359C>T

2 papers

NM_138554.5

p.R787H

c.2360G>A

1 paper

NM_138554.5

p.L788I

c.2362C>A

1 paper

NM_138554.5

p.G765C

c.2293G>T

1 paper

NM_138554.5

p.A764A

c.2292T>C