Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.R810Q

c.2429G>A

Surrounding Variants

1 paper

NM_138554.5

p.R810*

c.2428C>T

1 paper

NM_138554.5

p.R812K

c.2435G>A

1 paper

NM_138554.5

p.K813Q

c.2437A>C

1 paper

NM_138554.5

p.K813E

c.2437A>G

1 paper

NM_138554.5

p.K813R

c.2438A>G

1 paper

NM_138554.5

p.A814T

c.2440G>A

1 paper

NM_138554.5

p.H805R

c.2414A>G

2 papers

NM_138554.5

p.R804Q

c.2411G>A

5 papers

NM_138554.5

p.R804W

c.2410C>T

1 paper

NM_138554.5

p.D817N

c.2449G>A

1 paper

NM_138554.5

p.D817A

c.2450A>C

3 papers

NM_138554.5

p.G803E

c.2408G>A