Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003266.4

p.Q794K

c.2380C>A

NM_138554.5

p.Q834K

c.2500C>A

Surrounding Variants

1 paper

NM_138554.5

p.Q834R

c.2501A>G

1 paper

NM_138554.5

p.Q834H

c.2502G>C

1 paper

NM_138554.5

p.Q834H

c.2502G>T

1 paper

NM_138554.5

p.E835K

c.2503G>A

1 paper

NM_138554.5

p.G825E

c.2474G>A

2 papers

NM_138554.5

p.E824Q

c.2470G>C

4 papers

NM_138554.5

p.P823T

c.2467C>A

1 paper

NM_138554.5

p.S820*

c.2459C>A

1 paper

NM_138554.5

p.S820*

c.2459C>G

1 paper

NM_138554.5

p.D817A

c.2450A>C

1 paper

NM_138554.5

p.D817N

c.2449G>A

1 paper

NM_138554.5

p.A814T

c.2440G>A