Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.D41E

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
5 papers
NM_016562.4
p.D41E
c.123T>A
Surrounding Variants
5 papers
NM_016562.4
p.D41E
c.123T>G
1 paper
NM_016562.4
p.D41V
c.122A>T
1 paper
NM_016562.4
p.L40L
c.118C>T
1 paper
NM_016562.4
p.V49ins0
c.145_147dupGTG
1 paper
NM_016562.4
p.D50Y
c.148G>T
1 paper
NM_016562.4
p.T33P
c.97A>C
1 paper
NM_016562.4
p.T52T
c.156A>T
1 paper
NM_016562.4
p.D53D
c.159C>T
9 papers
NM_016562.4
p.R28G
c.82A>G
4 papers
NM_016562.4
p.T57T
c.171A>T
1 paper
NM_016562.4
p.I19F
c.55A>T
1 paper
NM_016562.4
p.I18I
c.54A>T
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