Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.I174R

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_016562.4
p.I174R
c.521T>G
Surrounding Variants
1 paper
NM_016562.4
p.I176L
c.526A>T
1 paper
NM_016562.4
p.A172A
c.516C>T
1 paper
NM_016562.4
p.L177F
c.529C>T
1 paper
NM_016562.4
p.L179R
c.536T>G
1 paper
NM_016562.4
p.Q181K
c.541C>A
1 paper
NM_016562.4
p.Q181*
c.541C>T
1 paper
NM_016562.4
p.Q181R
c.542A>G
1 paper
NM_016562.4
p.N182Y
c.544A>T
1 paper
NM_016562.4
p.C183S
c.547T>A
1 paper
NM_016562.4
p.C183S
c.548G>C
1 paper
NM_016562.4
p.R186*
c.556C>T
1 paper
NM_016562.4
p.R186Q
c.557G>A
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