Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.N314D

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_016562.4
p.N314D
c.940A>G
Surrounding Variants
1 paper
NM_016562.4
p.N314S
c.941A>G
4 papers
NM_016562.4
p.F310L
c.930T>A
4 papers
NM_016562.4
p.F310L
c.930T>G
4 papers
NM_016562.4
p.F310L
c.928T>C
1 paper
NM_016562.4
p.Q303R
c.908A>G
1 paper
NM_016562.4
p.L302P
c.905T>C
1 paper
NM_016562.4
p.L326L
c.976T>C
9 papers
NM_016562.4
p.S301P
c.901T>C
1 paper
NM_016562.4
p.K328E
c.982A>G
1 paper
NM_016562.4
p.E329Q
c.985G>C
2 papers
NM_016562.4
p.E329G
c.986A>G
1 paper
NM_016562.4
p.E329V
c.986A>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."