Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.Y356S

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_016562.4
p.Y356S
c.1067A>C
Surrounding Variants
1 paper
NM_016562.4
p.L353P
c.1058T>C
1 paper
NM_016562.4
p.M360V
c.1078A>G
1 paper
NM_016562.4
p.N361S
c.1082A>G
1 paper
NM_016562.4
p.Q364*
c.1090C>T
1 paper
NM_016562.4
p.L345L
c.1035G>A
3 papers
NM_016562.4
p.Q344H
c.1032A>T
1 paper
NM_016562.4
p.S368S
c.1104A>C
7 papers
NM_016562.4
p.L372M
c.1114C>A
1 paper
NM_016562.4
p.L372L
c.1114C>T
1 paper
NM_016562.4
p.S341_L342delFs
c.1021_1025del5
1 paper
NM_016562.4
p.L375fs
c.1123_1124fs
1 paper
NM_016562.4
p.L375_R376delFs
c.1125_1126delGC
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."