Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.N398S

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_016562.4
p.N398S
c.1193A>G
Surrounding Variants
1 paper
NM_016562.4
p.L396V
c.1186C>G
1 paper
NM_016562.4
p.N395K
c.1185T>A
1 paper
NM_016562.4
p.N395K
c.1185T>G
1 paper
NM_016562.4
p.L402L
c.1206T>G
1 paper
NM_016562.4
p.G405del1
c.1213_1214delGGC
1 paper
NM_016562.4
p.A412P
c.1234G>C
1 paper
NM_016562.4
p.A412A
c.1236T>C
1 paper
NM_016562.4
p.S415N
c.1244G>A
1 paper
NM_016562.4
p.V381I
c.1141G>A
1 paper
NM_016562.4
p.V381F
c.1141G>T
2 papers
NM_016562.4
p.R376Q
c.1127G>A
1 paper
NM_016562.4
p.L375_R376delFs
c.1125_1126delGC
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."