Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.M603I

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_016562.4
p.M603I
c.1809G>C
Surrounding Variants
1 paper
NM_016562.4
p.M603I
c.1809G>A
1 paper
NM_016562.4
p.M603I
c.1809G>T
1 paper
NM_016562.4
p.S610C
c.1829C>G
1 paper
NM_016562.4
p.L595Q
c.1784T>A
1 paper
NM_016562.4
p.E617A
c.1850A>C
1 paper
NM_016562.4
p.I585V
c.1753A>G
1 paper
NM_016562.4
p.R627I
c.1880G>T
6 papers
NM_016562.4
p.H630Y
c.1888C>T
2 papers
NM_016562.4
p.N576D
c.1726A>G
1 paper
NM_016562.4
p.V570V
c.1710T>A
1 paper
NM_016562.4
p.N640K
c.1920C>A
1 paper
NM_016562.4
p.N640K
c.1920C>G
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