Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.S663R

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_016562.4
p.S663R
c.1989T>G
Surrounding Variants
1 paper
NM_016562.4
p.S663R
c.1989T>A
1 paper
NM_016562.4
p.S663R
c.1987A>C
3 papers
NM_016562.4
p.I657T
c.1970T>C
1 paper
NM_016562.4
p.F670fs
c.2008_2009fs
3 papers
NM_016562.4
p.F670fs
c.2008_2009fs
1 paper
NM_016562.4
p.F670_D671delFs
c.2010_2011delTG
1 paper
NM_016562.4
p.D671_G672insFs
c.2013_2014insC
1 paper
NM_016562.4
p.E654K
c.1960G>A
1 paper
NM_016562.4
p.F646F
c.1938C>T
5 papers
NM_016562.4
p.K684*
c.2050A>T
1 paper
NM_016562.4
p.N640K
c.1920C>A
1 paper
NM_016562.4
p.N640K
c.1920C>G
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