Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.R920K

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
10 papers
NM_016562.4
p.R920K
c.2759G>A
Surrounding Variants
2 papers
NM_016562.4
p.E929Q
c.2785G>C
1 paper
NM_016562.4
p.V908L
c.2722G>C
5 papers
NM_016562.4
p.W933R
c.2797T>A
5 papers
NM_016562.4
p.W933R
c.2797T>C
1 paper
NM_016562.4
p.P935A
c.2803C>G
1 paper
NM_016562.4
p.L943I
c.2827C>A
1 paper
NM_016562.4
p.Y897C
c.2690A>G
1 paper
NM_016562.4
p.Y897D
c.2689T>G
2 papers
NM_016562.4
p.A893S
c.2677G>T
1 paper
NM_016562.4
p.S950G
c.2848A>G
1 paper
NM_016562.4
p.K951R
c.2852A>G
2 papers
NM_016562.4
p.C889Y
c.2666G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."