Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.S21T

c.61T>A

Surrounding Variants

1 paper

NM_138636.5

p.S21A

c.61T>G

1 paper

NM_138636.5

p.C22R

c.64T>C

1 paper

NM_138636.5

p.E23E

c.69G>A

3 papers

NM_016610.4

p.I36V

c.106A>G

NM_138636.5

p.I18V

c.52A>G

1 paper

NM_138636.5

p.L17Q

c.50T>A

1 paper

NM_138636.5

p.L16M

c.46C>A

1 paper

NM_138636.5

p.A26S

c.76G>T

1 paper

NM_138636.5

p.A26A

c.78C>T

1 paper

NM_138636.5

p.F15S

c.44T>C

1 paper

NM_138636.5

p.F15C

c.44T>G

1 paper

NM_138636.5

p.F15delFs

c.45delC

1 paper

NM_138636.5

p.I14T

c.41T>C