Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.G119E

c.356G>A

Surrounding Variants

1 paper

NM_138636.5

p.D118E

c.354C>A

3 papers

NM_138636.5

p.D118D

c.354C>T

1 paper

NM_138636.5

p.S111S

c.333A>G

1 paper

NM_138636.5

p.E129G

c.386A>G

1 paper

NM_138636.5

p.I109V

c.325A>G

1 paper

NM_138636.5

p.G108C

c.322G>T

1 paper

NM_138636.5

p.D134Y

c.400G>T

1 paper

NM_138636.5

p.Q103R

c.308A>G

1 paper

NM_138636.5

p.H102Y

c.304C>T

1 paper

NM_138636.5

p.L144S

c.431T>C

1 paper

NM_138636.5

p.L144L

c.432G>A

1 paper

NM_138636.5

p.E146G

c.437A>G