Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.L153R

c.458T>G

Surrounding Variants

1 paper

NM_138636.5

p.E150A

c.449A>C

1 paper

NM_138636.5

p.I158M

c.474A>G

1 paper

NM_138636.5

p.E146E

c.438G>A

1 paper

NM_138636.5

p.E146G

c.437A>G

1 paper

NM_138636.5

p.I161I

c.483A>T

1 paper

NM_138636.5

p.L144L

c.432G>A

1 paper

NM_138636.5

p.L144S

c.431T>C

1 paper

NM_138636.5

p.K163T

c.488A>C

1 paper

NM_138636.5

p.E164D

c.492G>C

1 paper

NM_138636.5

p.E164D

c.492G>T

1 paper

NM_138636.5

p.I166F

c.496A>T

1 paper

NM_138636.5

p.S167P

c.499T>C