Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.L318H

c.953T>A

Surrounding Variants

1 paper

NM_138636.5

p.F320I

c.958T>A

1 paper

NM_138636.5

p.V315V

c.945G>A

1 paper

NM_138636.5

p.Y322*

c.966T>A

1 paper

NM_138636.5

p.Y322*

c.966T>G

1 paper

NM_138636.5

p.V324V

c.972G>A

1 paper

NM_138636.5

p.G325*

c.973G>T

1 paper

NM_138636.5

p.P311insFs

c.931_932insA

1 paper

NM_138636.5

p.N309N

c.927T>C

1 paper

NM_138636.5

p.A305A

c.915C>T

1 paper

NM_138636.5

p.L333*

c.998T>G

1 paper

NM_138636.5

p.I302T

c.905T>C

1 paper

NM_138636.5

p.P337T

c.1009C>A