Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.S345F

c.1034C>T

Surrounding Variants

1 paper

NM_138636.5

p.D343D

c.1029C>T

1 paper

NM_138636.5

p.R338H

c.1013G>A

1 paper

NM_138636.5

p.P337P

c.1011C>T

1 paper

NM_138636.5

p.P337R

c.1010C>G

1 paper

NM_138636.5

p.P337T

c.1009C>A

1 paper

NM_138636.5

p.P337S

c.1009C>T

2 papers

NM_138636.5

p.P354L

c.1061C>T

1 paper

NM_138636.5

p.L333*

c.998T>G

1 paper

NM_138636.5

p.R361*

c.1081A>T

1 paper

NM_138636.5

p.R361K

c.1082G>A

1 paper

NM_138636.5

p.G325*

c.973G>T

1 paper

NM_138636.5

p.V324V

c.972G>A