Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.G402G

c.1206T>G

Surrounding Variants

1 paper

NM_138636.5

p.N404N

c.1212T>C

1 paper

NM_138636.5

p.F405F

c.1215T>C

1 paper

NM_138636.5

p.D410N

c.1228G>A

1 paper

NM_138636.5

p.F411F

c.1233C>T

3 papers

NM_138636.5

p.L413F

c.1237C>T

3 papers

NM_138636.5

p.M391T

c.1172T>C

1 paper

NM_138636.5

p.P389_L390insFs

c.1167_1168insC

1 paper

NM_138636.5

p.D386N

c.1156G>A

1 paper

NM_138636.5

p.D386Y

c.1156G>T

1 paper

NM_138636.5

p.E384V

c.1151A>T

1 paper

NM_138636.5

p.R383R

c.1149A>G

1 paper

NM_138636.5

p.E421E

c.1263A>G