Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.F470L

c.1410C>G

Surrounding Variants

1 paper

NM_138636.5

p.F470L

c.1410C>A

1 paper

NM_138636.5

p.F470L

c.1408T>C

1 paper

NM_138636.5

p.S465L

c.1394C>T

1 paper

NM_138636.5

p.S456*

c.1367C>G

1 paper

NM_138636.5

p.R454Q

c.1361G>A

1 paper

NM_138636.5

p.D487G

c.1460A>G

1 paper

NM_138636.5

p.L490L

c.1470C>A

4 papers

NM_138636.5

p.H450H

c.1350T>C

1 paper

NM_138636.5

p.N491S

c.1472A>G

1 paper

NM_138636.5

p.S492N

c.1475G>A

4 papers

NM_138636.5

p.F494L

c.1480T>C

5 papers

NM_138636.5

p.F494L

c.1482C>A