Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.P530P

c.1590T>C

Surrounding Variants

1 paper

NM_138636.5

p.P530P

c.1590T>A

1 paper

NM_138636.5

p.P530P

c.1590T>G

1 paper

NM_138636.5

p.P530H

c.1589C>A

1 paper

NM_138636.5

p.I529V

c.1585A>G

1 paper

NM_138636.5

p.F526C

c.1577T>G

1 paper

NM_138636.5

p.D536A

c.1607A>C

1 paper

NM_138636.5

p.S522N

c.1565G>A

1 paper

NM_138636.5

p.S522T

c.1565G>C

1 paper

NM_138636.5

p.L521F

c.1563A>C

1 paper

NM_138636.5

p.R541G

c.1621A>G

1 paper

NM_138636.5

p.Q519*

c.1555C>T

1 paper

NM_138636.5

p.L542P

c.1625T>C